RNA Details
Disease Name
idiopathic pulmonary fibrosis
Tissue
lung
RNA Symbol
Acta2
RNA ID
RNA Type
mRNA
Alteration Pattern
dna methylation
Species
rattus norvegicus
Detection Methods
Electrophoretic mobility shift assay; qRT-PCR; etc.
Target
NA
Pathway
NA
PubMed ID
Title
Essential role of MeCP2 in the regulation of myofibroblast differentiation during pulmonary fibrosis
Year
2011
Function
"Methyl CpG binding protein 2 (MeCP2) can bind to the methylated a-SMA gene. Suppression of MeCP2 gene expression caused significant reduction of a-SMA gene expression. In contrast, transient transfection of MeCP2 expression plasmid into fibroblasts enhanced a-SMA gene expression. MeCP2-deficient mice exhibited significantly decreased alveolar wall thickness, inflammatory cell infiltration, interstitial collagen deposition, and myofibroblast differentiation in response to endotracheal injection of bleomycin. Thus, MeCP2 is essential for myofibroblast differentiation and pulmonary fibrosis."